Glycogen Metabolism. Exploring the routes through liver and muscle Phosphorylase inhibition
Glycogen metabolism, which is a key pathway within the body’s system, has large amounts of glycogen in both the liver as well as the skeletal muscles. We set out to better understand these pathways through a number of experiments. We first inhibited liver-phosphorylase, and saw a decrease in blood glucose. It is liver phosphorylase that is responsible for the digestion of glycogen and the release into the bloodstream. By inhibiting this enzyme, we stopped the glucose being released to the bloodstream. The next step was to inhibit muscle phosphorylase. However, this had no impact on blood glucose levels. The reason is that muscle phosphorylase is more responsible for the synthesis than for its breakdown. (Chen, et al. 2019, 2019). By inhibiting this enzyme we were able to stop the synthesis and release of glycogen into the bloodstream, however, it did not alter the metabolism or release of glucose. The blood glucose level remained the same. Cont….