Krabbe Disease: The Accumulation Of Lipids
Krabbe disease (also known as globoid-cell leukodystrophy) is rare and affects the nervous systems. It is caused by a deficiency in the enzyme galactocerebrosidase, which is responsible for breaking down certain lipids, including ceramide, sphingosine, galactosphingosine, and galactosylceramide (Kumar & Dutta, 2020). This deficiency causes lipid accumulation in the body which can cause nerve cell damage.
These lipids are a hallmark of Krabbe Disease (Brennen and colleagues, 2018). Galactosylceramide (ceramide) and galactosylceramide (2021) are two of the most prevalent lipids that accumulate in Krabbe-related patients. Galactosphingosine, sphingosine, and ceramide have been also identified as lipids found in Krabbe Disease (Moreau, et al. 2016).
Also, Krabbe disease can lead to a buildup of ceramide and sphingosine. These lipids accumulate in Krabbe disease and are a sign of deficiency. Cont….
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