St. John’s Wort, Omega-3 and SAM-e Drug Interactions
St. John’swort has been shown to interact with many medications in significant ways. In a 2018 study published in Journal of Clinical Psychopharmacology, St. John’s wort was found to interact with antidepressants, antiretrovirals and anticoagulants. Nonsteroidal anti-inflammatory medications (Haight et. al., 2018,) can also cause St. John’s wort to reduce oral contraceptives’ effectiveness and increase bleeding risk. Some medications can interact with Omega-3 fatty acids. The American Journal of Clinical Nutrition published a 2018 review that found omega-3 fatty acid can cause bleeding and interfere with certain anticoagulants (McNamara and co-authors, 2018). SAM-e can interact with antidepressants, antipsychotics, and other medications (De Vry, et al. (2018). Folic acid is known to have very limited drug-drug interactions. Woo and colleagues (2018) published a 2018 review in Drug Safety that found no evidence of significant drug interactions with Folic acid. It is worth noting that folic acids can cause side effects in certain drugs, like methotrexate or sulfasalazine. These medications are used for autoimmune and inflammatory disorders (Woo and al. 2018). Cont…
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