The Position of Electrostatic Repulsion within the Folding of RNA Molecules
RNA molecules are composed of nucleotide bases which can be joined collectively by a phosphate spine. When these molecules fold into compact constructions, the cost repulsion between the phosphate teams could cause the molecules to stay unfolded. It’s because the negatively charged phosphate teams repel one another, stopping the molecules from folding appropriately. To resolve this drawback, a number of methods have been proposed. One strategy is to cut back the variety of phosphate teams. By decreasing the variety of phosphate teams, the electrostatic repulsion might be decreased and the molecules can fold appropriately. For instance, a examine by Li et al. (2020) confirmed that the discount of the variety of phosphate teams in an RNA molecule can result in a extra secure folded construction. One other strategy is to switch the construction of the phosphate teams in order that they now not repel one another. For instance, a examine by Dai et al. (2016) demonstrated that by introducing optimistic expenses into the phosphate teams, the molecules may very well be stabilized and folded appropriately. Cont…
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