The role of the Triose phosphate Isomerase In Enabling Glucolysis
Triosephosphate Isomerase (TPI), an enzyme, plays a vital role in the enzymatic pathway that allows glycolysis to occur. It is where a glucose molecule gets broken down into two different pyruvate molecules. TPI converts dihydroxyacetone phosphate(DHAP) into glyceraldehyde-3-phosphate (“G3P”), allowing all of the glucose molecules to be used (Rashidi et.al., 2020). Only TPI can catalyze this interconversion. The glucose molecule is not converted into energy-storing molecules necessary to glycolysis without it (Gao, et al. 2016). The conserved enzyme TPI can be found in almost all organisms from bacteria to humans. The cytoplasm is where TPI can be found in humans. It is responsible for a variety of metabolic processes including glycolysis and gluconeogenesis as well as the pentose-phosphate pathway. (Li and al.,2021). Because of its multiple functions in these pathways, TPI is an important enzyme for all cells. Cont…..
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