O’Methylguanine Mutation & Its Repair Mechanism
O’methylguanine can cause a number of genetic disorders. O’ methylguanine (also known as OMg) is a form of base modification where the guanine bases of a nucleotide are replaced with methylated guanines. The most widespread type of DNA damage, O’ methylguanine is the leading cause of genetic mutations such as those that lead to cancer or birth defects. (Sander, 2018). O’ methylguanine is a type of DNA repair that must be used by cells to fix it. This system relies on enzymatic reactions in order to repair the proper base sequence. (Kumar et al.,2019). O’methylguanine (OMGT) is vital for the repair of O’ methylguanine DNA mutations and the prevention of the accumulation. This enzyme can detect incorrect bases and replace them with the right one. This is used to fix the mutation and restore correct base sequence. OMGT also helps to prevent errors in DNA replication. (Zhang et al., 2021). Cont…
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