The Function of Argininosuccinate in Urea Cycle Metabolism: A Evaluate
The urea cycle is a metabolic pathway by which nitrogen from ammonia is transformed into urea and eradicated from the physique. The cycle entails 5 enzymes and 5 intermediates, together with argininosuccinate (AS). AS is an amino acid-like compound that’s transformed into arginine and fumarate by the enzyme argininosuccinate lyase (ASL). Arginine is then transformed into ornithine and urea is shaped. AS is a crucial intermediate within the urea cycle; it’s a element of the cycle that’s important for the elimination of extra nitrogen from the physique. The conversion of AS to arginine is catalyzed by the enzyme ASL and is the rate-limiting step of the cycle. Research have proven that ASL exercise is regulated by arginine and ornithine, and that the exercise of ASL might be elevated in response to elevated ranges of arginine and ornithine (Latif et al., 2016).
As well as, the exercise of ASL is modulated by the tip product of the cycle, urea, and by the concentrations of intermediates within the cycle, together with AS and arginine (Latif et al., 2016). Cont….
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