Beta Oxidation of MyristoylCoA: The Catabolic Technique of Fatty Acids
Beta oxidation is a metabolic course of that breaks down long-chain fatty acids into smaller molecules akin to acetyl-CoA. MyristoylCoA (C14:0) is one such fatty acid that’s topic to this breakdown course of. The method takes place within the mitochondria and is enabled by a lot of enzymes and cofactors. The preliminary step within the beta oxidation of myristoylCoA is the dehydrogenation of the fatty acid, catalyzed by the enzyme acyl-CoA dehydrogenase. This removes two hydrogen atoms from the fatty acid and leads to the formation of trans-2-enoyl-CoA (Kumar, et al., 2018). Subsequently, the enzyme enoyl-CoA hydratase catalyzes the addition of a water molecule to the trans-2-enoyl-CoA, leading to L-3-hydroxyacyl-CoA (Kumar, et al., 2018). Following this, the enzyme L-3-hydroxyacyl-CoA dehydrogenase removes one other pair of hydrogen atoms, forming 3-ketoacyl-CoA (Kumar, et al., 2018). The beta oxidation of myrositoylcoa is a metabolic course of for the oxidative breakdown of fatty acids to generate vitality within the type of ATP molecules. This course of includes 4 enzymatic steps, starting with the activation of the fatty acid by acyl-CoA synthetase (Acs), which makes use of ATP to kind myrositoyl-CoA (McA) from myrositoyl (M) and coenzyme A (CoA) (Ahmed et al., 2020). Cont…
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