Toxicity, Absorption, and Distribution: An Overview
Toxicity, absorption, and distribution are three key ideas within the research of pharmacology. Toxicity is the extent of hurt a substance may cause to an organism at a given dose (Kumar et al., 2019). Absorption is the method of a drug coming into the bloodstream and being transported to tissues and organs the place it has an impact (Yang et al., 2016). Distribution is the method of a drug or different substance shifting by the physique, together with the motion of drug molecules from the bloodstream to tissues and organs the place it has an impact (Liu et al., 2020). These three ideas are important to understanding how medicine work together with the physique. A drug’s toxicity will depend on the dose, the route of administration, the goal tissue, and different components. The speed and extent of absorption of a drug rely on its solubility within the gastrointestinal tract, the pH of the gastrointestinal tract, and the speed at which it’s metabolized (Kumar et al., 2019). The distribution of a drug includes the transport of drug molecules to focus on tissues and organs, and might be affected by the drug’s lipophilicity, its protein binding, and different components (Liu et al., 2020). Cont…
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